• Saturday, February 18, 2012
February 18, 2012, 02:17:53 PM *
Welcome, Guest. Please login or register.

Login with your Chronicle username and password
News: For all you tweeters, follow The Chronicle on Twitter.
 
Pages: [1] 2
  Print  
Author Topic: This month in academic medicine  (Read 2008 times)
pikachu
Senior member
****
Posts: 818

TT at an RU/VH


« on: August 20, 2009, 08:33:01 PM »

(or ask your pharmaceutical what ghostwritting can do for you)

http://www.nytimes.com/2009/08/05/health/research/05ghost.html

http://www.boston.com/news/nation/articles/2009/08/20/glaxosmithkline_used_ghostwriting_to_promote_paxil/

http://www.nytimes.com/2009/08/19/health/research/19ethics.html
Logged

I am not afraid to get mavericky in here....
sciencephd
Distinguished Senior Member
*****
Posts: 6,040


« Reply #1 on: August 20, 2009, 08:53:44 PM »


The faculty who put their names on these things are the worst sleazes, as it is their academic endoresement that provides the credibility.  They are the ones who should be providing the "filter".
Logged

I just hate it that I constantly have to like everyone and everything. -- moonstone

O, what a hateful feminist concoction!
Jews, communists, "lesbians", feminists and marihuana addicts  --Pyshnov
jackit
Uppity
Distinguished Senior Member
*****
Posts: 2,702

'Til the cows drive home.


« Reply #2 on: August 20, 2009, 08:54:07 PM »

Yep.  This is medicine's 'pedophile scandal.'

I thought I knew 'how things work,' but I found myself shocked at how successfully the drug companies co-opted scientist-physicians.

An interesting question is what sort of reform should be introduced to avoid this in the future.
Logged

doctor_torrseal
Senior member
****
Posts: 589


« Reply #3 on: August 21, 2009, 04:48:23 PM »

Thanks.  I had thought about posting a link to the NYT article but did not get around to it.

I knew that researchers were sometimes in bed with pharma companies, but even so I was stunned by the ... blatantness? blatancy? OK, blatant violation of what I thought I knew about research and publishing ethics.

In my field, there isn't the same kind of money at stake so the situation wouldn't arise, but even the biggest unethical powermongers would know not to do such a thing.  I am curious to hear if anyone thinks this is partly an MD vs. PhD cultural difference.  MDs just do not get the same type of training in research and certainly I've heard biologists complain about the effects of this on quality of research; perhaps it also extends to what some (not all) MDs consider to be ethical in research and publication.
Logged
prytania3
Distinguished Senior Member
*****
Posts: 36,698

Prytania, the Foracle


« Reply #4 on: August 21, 2009, 08:38:06 PM »

I'd do it in a minute, but then I'm a sleaze. I'm also in English.
Logged

Clowns, I tell you. Clowns.
doctor_torrseal
Senior member
****
Posts: 589


« Reply #5 on: August 22, 2009, 05:24:23 AM »

I'd do it in a minute, but then I'm a sleaze. I'm also in English.

But what's truly horrifying is that the articles give no indication that Wyeth or Glaxo paid the doctors for the use of their names as lead "authors"!  The article-writing and placing company got paid, but for all we can tell, the doctors did it purely (ha ha, "purely") for the prestige, power, influence, and CV-padding that "writing" a review article brings.

I mean, my integrity has a price, too.  But I'd like to think it isn't that cheap.
Logged
tenured_feminist
Distinguished Senior Member
*****
Posts: 7,334


« Reply #6 on: August 23, 2009, 06:55:59 AM »

Yeah, I saw this too and thought it was way beyond the pale. WTF is wrong with these people and their institutions?

Does anything happen now? Do they get a scolding from their dean? Barred from receiving merit pay for five years? Required to remove this stench-laden sh!t from their CVs? A formal bad-dog letter in their permanent records? Or do we all just shake our heads sadly and move on?
Logged

Quote
You people are not fooling me. I know exactly what occurred in that thread, and I know exactly what you all are doing.
pikachu
Senior member
****
Posts: 818

TT at an RU/VH


« Reply #7 on: August 23, 2009, 10:01:03 AM »

It is obvious to me that the administration doesn't want to deal with the problem and would rather deny it and pretend it is not happening. That's probably because the faculty who are part of the ghostwritting also bring huge amounts of grant money, private or federal. Unfortunately the pharmaceutical sector and academic medicine are too closely connected. Here is an excellent article (available online) published in American Psychologist (flagship journal of APA). Just read their findings that appear in bulleted points throughout the article, and pertain to issues such as inappropriate influence of pharmaceuticals on clinical practice, research, legislation, and medical education. Some highlights:

Source: Pachter, W. S., Fox, R. E., Zimbardo, P., & Antonuccio, D. O. (2007). Corporate funding and conflicts of interest: A primer for psychologists. American Psychologist, 62, 1005-1015.

http://www.apa.org/journals/releases/amp6291005.pdf

"● The pharmaceutical industry influences most aspects of the American health care system that are relevant to its business interests: nonprofit patient groups (Ginsberg, 2006), physicians (Choudhry, Stelfox, & Detsky, 2002), professional and academic institutions, the U.S. Congress, and the Food and Drug Administration (FDA; Antonuccio et al., 2003; Drinkard, 2005; Relman & Angell, 2002).

● Pharmaceutical industry money is so crucial to the funding of university medical centers that no threats or offers need to be made for a company to exert its influence (CSPI, 2003b; Elliott, 2001a).

● The pharmaceutical industry has the largest lobbying force of any industry (Drinkard, 2005; Relman & Angell, 2002). The pharmaceutical and health products industry spent $612 million on lobbying from 1998 to 2005, working on more than 1,400 congressional bills (Center for Public Integrity, 2006).

● In 2001, the pharmaceutical industry spent over $19 billion on marketing (Antonuccio et al., 2003). It has been estimated that $35 billion was spent that year on “marketing masquerading as education” and “marketing masquerading as research,” costs that were then passed on to the public via higher retail prices for the medicines they purchased (Angell, 2004).

● Overwhelming data show that researchers funded by pharmaceutical companies that sell the drug they are evaluating tend to produce results favorable to that drug (Bekelman, Le, & Gross, 2003; Bhandari et al., 2004; Bodenheimer, 2000; Coyle, 2002b; Lexchin, Bero, Djulbegovic, & Clark, 2003). For example, 96% of researchers writing favorably about a drug for hypertension were funded by the manufacturer that produced and sold that drug, but only 37% of those not funded by the company reported favorable results (Gorner, 2000).

● In search of easier profit, the thrust of industry supported research has shifted from trying to find causes and mechanisms of disease to certifying “me-too” drugs (copycats of negligible improvement or added value; Angell, 2004; Gorner, 2000).

● Almost half of medical school faculty members who serve on institutional review boards also serve as consultants to industry (Campbell et al., 2003). Moreover, institutional review board members do not always disclose their financial relationships with industry, even when they are making decisions about research protocols sponsored by the company with which they have a relationship or by a competing company (Campbell et al., 2006).

● The pharmaceutical industry is biasing the evidence base by increasing their control of investigators, research designs, and when or whether results are published (Bodenheimer, 2000; Bodenheimer & Collins, 2001; Lexchin et al., 2003; Melander, Ahlqvist-Rastad, Meijer, & Beermann, 2003; Vedantam, 2001).

● Evidence of the potentially extensive role of ghost writing (i.e., industry-authored publications in which the identified authors may have never actually seen the raw data) in the scientific literature (e.g., Healy, 2006; Healy & Cattell, 2003; Mowatt et al., 2002) highlights the problem of poor access to raw scientific data. Despite a 1999 law ostensibly requiring public disclosure of raw data from NIH funded studies, all requests for data access to date have been denied (Lenzer, 2006).

● Some corporations have pilloried and intimidated academicians whose research was viewed as contrary to the interests of the corporation (Needleman,1992). Several pharmaceutical firms have threatened researchers (Bodenheimer & Collins, 2001; Morin & Deane, 2003), interrupted trials, and blocked publication of unfavorable results (Bok, 2003; Greenberg, 2003)."

Again, these are just some highlights. Read all the bulleted points in the article to get a picture of the extent of the problem.


Logged

I am not afraid to get mavericky in here....
prytania3
Distinguished Senior Member
*****
Posts: 36,698

Prytania, the Foracle


« Reply #8 on: August 23, 2009, 04:46:24 PM »

I'd do it in a minute, but then I'm a sleaze. I'm also in English.

But what's truly horrifying is that the articles give no indication that Wyeth or Glaxo paid the doctors for the use of their names as lead "authors"!  The article-writing and placing company got paid, but for all we can tell, the doctors did it purely (ha ha, "purely") for the prestige, power, influence, and CV-padding that "writing" a review article brings.

I mean, my integrity has a price, too.  But I'd like to think it isn't that cheap.

Oh yeah. I don't write my name unless I get paid.

(except on the CHE)
« Last Edit: August 23, 2009, 04:47:43 PM by prytania3 » Logged

Clowns, I tell you. Clowns.
jackit
Uppity
Distinguished Senior Member
*****
Posts: 2,702

'Til the cows drive home.


« Reply #9 on: August 23, 2009, 10:55:08 PM »

Awesome post, pikachu.

And scary.
Logged

runwithscissors
Senior member
****
Posts: 350


« Reply #10 on: August 24, 2009, 03:52:51 AM »

Pikachu, reading that made me actually shudder. I got the someone's walking on my grave feeling. Then I realised it was a big pharma rep doing a little dance on my gravestone.
Logged

"Space is invisible mind dust, and stars are but wishes"
mozman
Distinguished Senior Member
*****
Posts: 1,083


« Reply #11 on: August 25, 2009, 06:48:37 AM »

The rats are beginning to abandon ship...

http://chronicle.com/article/McGill-U-Professor-Admits/48164/

This should be fun to watch.

mm

« Last Edit: August 25, 2009, 06:49:12 AM by mozman » Logged

Could you grow the foot into another patient? I mean, you are a scientist.
inthelab
Where beloved molecules abide
Distinguished Senior Member
*****
Posts: 4,241

Who knew?


WWW
« Reply #12 on: August 25, 2009, 07:41:36 AM »

True story:
I was recruited by a big Pharma company (don't want to say which on these fora) 3 years ago to ghost-write such articles and recruit the docs.
I was appalled.  I told the searching supervisor why it was wrong, from the context of journal rules.
The next day my big VA grant was funded.
Logged

jackit
Uppity
Distinguished Senior Member
*****
Posts: 2,702

'Til the cows drive home.


« Reply #13 on: August 25, 2009, 09:08:52 AM »

True story:
I was recruited by a big Pharma company (don't want to say which on these fora) 3 years ago to ghost-write such articles and recruit the docs.
I was appalled.  I told the searching supervisor why it was wrong, from the context of journal rules.
The next day my big VA grant was funded.

I love to see karma behave itself.
Logged

pikachu
Senior member
****
Posts: 818

TT at an RU/VH


« Reply #14 on: September 02, 2009, 05:04:42 PM »

The psychopathic crooks are back. The bad news is that they continuously and unremorsefully try to bribe and deceive doctors to prescribe medications for unapproved uses and doses, resulting in patient deaths. The good news though is that, at the end of the day, business is good and they are expanding.

http://news.yahoo.com/s/ap/20090902/ap_on_go_ca_st_pe/us_pfizer_settlement

" Federal prosecutors hit Pfizer Inc. with a record-breaking $2.3 billion in fines Wednesday and called the world's largest drug maker a repeating corporate cheat for illegal drug promotions that plied doctors with free golf, massages, and resort junkets.
.......................
Authorities called Pfizer a repeat offender, noting it is the company's fourth such settlement of government charges in the last decade. The allegations surround the marketing of 13 different drugs, including big sellers such as Viagra, Zoloft, and Lipitor.
.........................
Loucks said that even as Pfizer was negotiating deals on past misconduct, they were continuing to violate the very same laws with other drugs.
..............................
"There's a kind of mentality in this sector that (settlements) are the cost of doing business and we can cheat...."
..................................
Authorities said Pfizer's salesmen and women created phony doctor requests for medical information in order to send unsolicited information to doctors about unapproved uses and dosages.
.................................
They said the junkets and other company-paid perks were designed to promote Bextra and other drugs, to doctors for unapproved uses and dosages, backed by false and misleading claims about safety and effectiveness.

Bextra, for instance, was approved for arthritis, but Pfizer promoted it for acute pain and surgical pain, and in dosages above the approved maximum. In 2005, Bextra, one of a class of painkillers known as Cox-2 inhibitors, was pulled from the U.S. market amid mounting evidence it raised the risk of heart attack, stroke and death.
................................
When Pfizer originally disclosed the settlement figure, it also announced plans to acquire rival Wyeth for $68 billion. That deal, which would bolster Pfizer's position as the world's top drug maker by revenue, is expected to close before year's end."

http://news.yahoo.com/s/ap/20090902/ap_on_go_ca_st_pe/us_pfizer_settlement



Logged

I am not afraid to get mavericky in here....
Pages: [1] 2
  Print  
 
Jump to:  

Powered by MySQL Powered by PHP Powered by SMF 1.1.9 | SMF © 2006-2008, Simple Machines LLC Valid XHTML 1.0! Valid CSS!