March 31, 2000

Soon the Human Genome Project Will Be Completed. What Then?

By FRANCIS S. COLLINS and KARIN JEGALIAN

The Human Genome Project, begun in 1990, is an international research program whose goal is to spell out the three billion letters of the DNA code in the nucleus of each human cell. By December 1999, more than a third of the genome -- the complete genetic program of human beings -- had been sequenced and was freely available in public databases (http://www.ncbi.nlm.nih.gov/genome/seq). In the next few months, a working draft of 90 percent of the genome will be

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