January 29, 1999

Geneticists Near End of Quest for Source of a Deadly Disease

By DAVID L. WHEELER

Scientists now test potential drugs for hereditary disorder

Christine Ambrose walked into her boss's office, holding up some film still wet from the developer. The pattern Ms. Ambrose saw indicated that an enormously frustrating 10-year search might be at its end.

Ms. Ambrose was eight months' pregnant and desperate to finish isolating a gene before she left on maternity leave. The head of the laboratory, Marcy E. MacDonald,

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